If you like to grow fruits and vegetables from seed at home, what’s the best way to avoid genetically modified seeds? The good news is that most GMO seeds are limited to larger-scale farming, and those crops are mostly things like corn, soybeans, cotton and crops for sugar production. For home gardeners, the only chance you’ll buy GMO seeds is for corn or squash, so to be extra sure, look for certified organic seeds. Otherwise, the likelihood the seeds at your store are GMO is very low. You can also look up seed companies that have signed a Safe Seed Pledge, which lists seed brands that have promised not to sell GMO seeds.