The healthiest way to keep your mattress free of germs and bacteria would be to wash it in hot water in your washing machine. But we all know this isn't possible, so do the next best thing: Give it a shot of alcohol. Strip the bed and fill a small spray bottle with cheap vodka or rubbing alcohol. Gently mist the top and sides of the mattress. The booze will kill the bacteria -- along with odors -- and won't saturate your bed, since the alcohol will quickly dissipate. Make this a regular habit for a healthy bed.