health

Acute Flaccid Myelitis Seen Mostly in Children

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | August 5th, 2019

Dear Doctor: What’s the latest on the new children’s disease that’s kind of like polio? It’s been all over the news, and like a lot of the moms around here, I’m getting worried.

Dear Reader: You’re referring to a rare and serious neurological condition that, as you mention, bears some striking similarities to polio. Known as acute flaccid myelitis, or AFM, it has thus far been seen mostly in children. AFM results in extreme muscle weakness and even paralysis, mainly of the arms and legs. At this time, the leading suspect is a virus that attacks and causes damage to the spinal cord. Unlike polio, which is known to be caused by the poliovirus and for which we have an effective vaccine, the specific cause of AFM is not yet known, and there is no vaccine.

Acute flaccid myelitis is not a new condition, but it has been on the rise in recent years. Due to this steady increase in cases, the Centers for Disease Control and Prevention began tracking the illness in 2014. There have been 570 confirmed cases of the condition since that time, with an average patient age of 5 years. Last year, a total of 233 confirmed cases of AFM occurred in 41 states. This played a role in the CDC’s decision to release an update about the condition in early July, which has put acute flaccid myelitis back into the headlines. The timing of this newest update is due to the observation that AFM has a “season,” with the number of cases spiking in late summer and early fall.

Although cases of AFM are reported each year, outbreaks appear to surge every two years. The CDC reports that so far in 2019, which according to the previous pattern is an “off” year for the condition, 11 cases of acute flaccid myelitis have been reported. However, because awareness of AFM is relatively recent, it’s likely that undiagnosed cases have not made it into the official tallies.

The majority of cases begin with fever and respiratory symptoms similar to a cold or the flu. This is followed by neurological difficulties such as weakness in the arms or legs, a decrease in reflexes, facial weakness, drooping eyelids, difficulty moving the eyes, slurred speech and trouble with swallowing. Occasionally, numbness or pain may be present, and in some cases, patients experience trouble breathing.

A lab test to diagnose the condition has not yet been developed, which makes vigilance by parents and health care providers about potential cases all the more important. Because the later symptoms of the condition can mirror those of other neurological diseases, such as Guillain-Barre syndrome, AFM is difficult to diagnose. There is no known cure, so at this time, treatment focuses on physical and occupational therapy to restore movement.

If your child shows symptoms of AFM, seek medical help immediately. Health care providers whose patients show symptoms of AFM have been directed by the CDC to immediately alert their state or local health departments. They should collect biological specimens to help identify the causes for the condition.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o UCLA Health Sciences Media Relations, 10880 Wilshire Blvd., Suite 1450, Los Angeles, CA, 90024. Owing to the volume of mail, personal replies cannot be provided.)

health

Drug-Resistant UTIs Are Harder to Treat

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | August 2nd, 2019

Dear Doctor: I had a urinary tract infection that improved on the antibiotic Keflex, but lab tests showed the bacteria was actually resistant to the Keflex, so I had to switch to a different antibiotic. I don’t understand -- if the infection was resistant, why did the symptoms go away?

Dear Reader: Urinary tract infections, or UTIs, are one of the most common bacterial infections in the U.S. They occur when bacteria -- in the majority of cases it’s E. coli -- colonize any of the tissues or structures of the urinary system. This includes the kidneys, which filter waste and excess water from the blood to make urine; the ureters, which are the tubes through which urine leaves the kidneys; the bladder, where urine is stored; and the urethra, through which urine leaves the body.

Although both men and women can get a UTI, the condition is more common in women. According to some estimates, anywhere from 40% to 60% of women will have at least one UTI in their lifetime. Symptoms can include urine that is dark, cloudy, bloody or pungent, an urgent need to urinate that yields very little urine, pain or burning during urination, and abdominal pain. In the elderly, a UTI can present without any physical symptoms, but result in confusion or temporary cognitive impairment.

Unfortunately, as you have experienced firsthand, urinary tract infections are becoming increasingly challenging to treat. This is due to the growing problem of drug-resistant pathogens, which affect an estimated 2 million people in the United States every year. Antibiotic resistance happens when drugs are no longer effective at completely eradicating the bacteria and fungi that cause infection and disease. That means that although some of the bacteria or fungi may be killed by the drug, others aren’t. Those that are resistant to the drug will continue to grow and reproduce, causing the disease or condition to persist.

We suspect that in your case, the initial antibiotic killed enough of the bacteria that were causing your UTI for the symptoms to abate and afford you physical relief. However, because the infection included bacteria that were resistant to Keflex, the UTI was not being cured. Those bacteria that were resistant to Keflex were continuing to grow. Fortunately, your health care provider followed the current guidelines to send a urine sample out to test for antibiotic resistance. Using the results of those lab tests, you were prescribed a different and ideally more effective antibiotic. In some cases, it can take multiple attempts with different antibiotics to successfully vanquish a UTI. Whichever drug is prescribed, be sure to ask about potential interactions with food or other drugs, and to complete the regimen, even after symptoms go away.

Because of the risk of the infection moving to the kidneys, it’s important to make sure that a UTI is completely cleared up. Patients whose urinary tract infection is caused by a drug-resistant strain of bacteria should continue to be followed after antibiotic therapy is complete. We recommend at least one repeat urine test to “test for cure” and make sure that the UTI has been completely eradicated.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o UCLA Health Sciences Media Relations, 10880 Wilshire Blvd., Suite 1450, Los Angeles, CA, 90024. Owing to the volume of mail, personal replies cannot be provided.)

health

Keep Vigilant to Prevent Rocky Mountain Spotted Fever

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | July 31st, 2019

Dear Doctor: My wife and I appreciate your articles about ticks, and we wonder if you could talk about Rocky Mountain spotted fever? A friend of ours here in Arkansas got really sick from it, and since our family is big on outdoor activities, we want to know what to look for.

Dear Reader: We’re glad the information about tick-borne infections and illnesses has been useful. We get quite a few questions on the topic, which reflects the growing awareness of ticks and the health dangers associated with them.

Rocky Mountain spotted fever, or RMSF, is a potentially deadly disease acquired when an individual is bitten by a tick infected with the bacterium Rickettsia rickettsii. Depending on the region, the disease is spread by the Rocky Mountain wood tick, the American dog tick or the brown dog tick. Although it has been found across wide areas of the United States, Rocky Mountain spotted fever is most often reported in Oklahoma, North Carolina, Missouri, Tennessee and in your home state of Arkansas. It can also be found in parts of the American Southwest and in Mexico.

As with many tick-borne diseases, initial signs of RMSF can be general enough that they are easily attributed to other causes, including a cold or the flu. Symptoms commonly include fever, headache, abdominal pain, nausea, vomiting and lethargy. The rash that usually accompanies RMSF often develops between two and four days after the initial infection, which adds to the challenge of a swift and accurate diagnosis. The rash can take a variety of forms, from bold red splotches to tiny pinpoint dots.

Although a laboratory test is needed to confirm RMSF, the Centers for Disease Control and Prevention urge health care providers to commence immediate treatment when clinical signs and symptoms, as well as a thorough health and travel history, point to the disease. Immediate treatment is crucial in cases of Rocky Mountain spotted fever, and waiting for confirmation from a lab test can put the patient at risk.

The recommended treatment for RMSF is the antibiotic doxycycline. Early treatment can prevent serious illness and death. When left untreated, the bacterium that causes Rocky Mountain spotted fever can cause extensive damage to blood vessels throughout the body, which leads to tissue and organ damage. Death can occur in as little as eight days after the onset of symptoms. At this time, there is no vaccine for RMSF, which makes prevention the only way to avoid infection.

Summer is high season for ticks. These tiny arachnids can be as small as a poppy seed early on in their life cycle, and since a tick bite is usually painless, ongoing vigilance is key. At the risk of repeating ourselves, this includes avoiding densely wooded and brushy areas, covering exposed skin with light-colored clothes, wearing closed-toed shoes, tucking pants into socks, using appropriate pesticides and doing visual body scans, including of pets. And check into local resources. Many communities throughout the U.S. have vector control agencies, which are devoted to the identification and control of dangerous local pests, including ticks.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o UCLA Health Sciences Media Relations, 10880 Wilshire Blvd., Suite 1450, Los Angeles, CA, 90024. Owing to the volume of mail, personal replies cannot be provided.)

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