health

Rare STD Causes Inflammation of Urethra

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | February 4th, 2019

Dear Doctor: My boyfriend and I were in London over the holidays, and we heard a lot about MG, a new sexually transmitted disease. Is it here in the United States too? Should I be worried?

Dear Reader: You're referring to Mycoplasma genitalium, also known as MG or Mgen. It's a bacterium that is transmitted through sexual contact, and as a result, can infect the reproductive tract. MG was first identified in the United Kingdom more than 30 years ago, so it's not really new. It was found in two men being treated for non-gonococcal urethritis, which is inflammation of the urethra, the tube that carries urine away from the bladder. "Non-gonococcal" means that the infection is not caused by the gonorrhea bacteria.

The Centers for Disease Control and Prevention only officially acknowledged the disease in 2015, so it's a fairly recent addition to the STD conversation. Although reliable statistics are not yet available, infection rates among women in the U.S. are estimated at about 1 percent. That's slightly higher than gonorrhea and lower than the rate of infection with chlamydia, which is 3 percent. However, when looking at high-risk populations, which constitutes young people who have multiple sexual partners and those who don't practice safe sex, some estimates of infection rates are as high as 20 percent.

Mycoplasma genitalium causes inflammation of the urethra in both men and women. Symptoms include an increased urge to urinate, as well as pain and burning, particularly during urination. Some cases are accompanied by an abnormal discharge. It's also possible for MG to produce no symptoms at all. A recent analysis of available data found that close to 60 percent of women who tested positive for MG had no symptoms. However, due to their reproductive anatomy, women face greater risks than men from infection. Among these is developing pelvic inflammatory disease, or PID, an infection of the female reproductive organs that can cause long-term health problems and can lead to infertility. The bacterium has also been linked to adverse birth outcomes, as well as to increased susceptibility to HIV infection.

Mycoplasma genitalium is challenging to diagnose. It lacks a cell wall, so it's not suitable for a gram stain, the most common technique for differentiating and identifying bacteria. It's so slow-growing that a culture takes six months to develop. Instead, nucleic acid amplification testing, or NAAT, which identifies the pathogen via its genetic material, is now being used. The test is typically done on urine in men and via cervical swabs in women. As with all bacterial infections, treatment is with antibiotics. And as with a growing number of bacterial pathogens, MG is developing antibiotic resistance.

As to whether people should be worried, if they have multiple partners and don't practice safe sex, the answer is yes. We're not referring only to MG infections when we say that. The number of new cases of sexually transmitted diseases, including chlamydia, gonorrhea and syphilis, reached an all-time high in 2017. That's part of a steep and sustained increase that has alarmed health care professionals. So, please, always practice safe sex. Anyone with any symptoms of a sexually transmitted disease should seek medical care immediately.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o UCLA Health Sciences Media Relations, 10880 Wilshire Blvd., Suite 1450, Los Angeles, CA, 90024. Owing to the volume of mail, personal replies cannot be provided.)

health

Adequate Amount of Vitamin D Is Essential to Good Health

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | February 1st, 2019

Dear Doctor: Why is it that vitamin D is so important? I know you can get it from food and supplements, but I'd like to get it the old-fashioned way -- from the sun. Is that too dangerous?

Dear Reader: It can't be overstated: Vitamin D is critical to good health. It's needed for calcium absorption from the intestinal tract, and for the regulation of blood phosphorus levels. Both of these are essential to developing and maintaining strong and healthy bones. Even when you get enough calcium and phosphorus in your diet, you can't absorb it unless you're also getting enough vitamin D.

Without adequate vitamin D, bones become thin and brittle and can easily bend or break. Rickets was once a widespread disorder in which children's bones were so thin and spongy from a lack of the vitamin that their skeletons failed to develop properly. In some cases, their legs became visibly bowed. Since the addition of D to milk, yogurt, breakfast cereals and orange juice, rickets has largely been wiped out.

Vitamin D also plays a vital role in brain development, muscle function, maintaining a healthy respiratory and immune system, and in optimal cardiac function. Recent research has also uncovered a potential link between a deficiency of vitamin D and depression. In fact, we now know that vitamin D receptors are present in virtually every tissue, so we fully expect research to continue to discover even more ways in which the vitamin is essential.

As you point out in your question, our bodies manufacture vitamin D in response to sunlight. That's why it's also known as the "sunshine vitamin." Specifically -- and this is a bit of a deep dive, but we think it's fascinating -- the process of vitamin D synthesis begins when ultraviolet rays strike the skin. This triggers a chemical process known as hydroxylation, which involves the liver, kidneys and certain cellular structures, and ultimately creates the chemical compound that we refer to as vitamin D. This process of synthesis also takes place with the vitamin D that we get from food and supplements.

The challenge is that getting enough D from sun exposure can take vigilance. Variables include air pollution, cloud cover, latitude, time of year, time of day, clothing, the use of sunscreen, and an individual's skin type, age and lifestyle. Each of these can make it more difficult to get enough D.

To trigger vitamin D synthesis in the body, the general recommendation is to spend between 10 to 30 minutes with arms, legs and/or torso exposed to sunlight during peak hours -- without sunscreen -- two to three times per week. Melanin protects the skin from sun damage, so darker skin requires longer exposure. For those who prefer not to deal with the potential risks of sun exposure, good dietary sources of D include the fortified foods we just mentioned, as well as fatty fish such as salmon, tuna and mackerel, and fish liver oils. The vitamin is also present in beef liver and egg yolks, but in small amounts. And if you decide to take supplements, please be sure to follow the dosage guidelines. For all its many benefits, it's possible to get too much vitamin D.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o UCLA Health Sciences Media Relations, 10880 Wilshire Blvd., Suite 1450, Los Angeles, CA, 90024. Owing to the volume of mail, personal replies cannot be provided.)

health

FDA Recalls Numerous Blood Pressure Drugs

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | January 30th, 2019

Dear Doctor: I've been taking a drug for blood pressure issues for a couple of years, but now I hear it's being recalled. What's the risk? Should I stop taking it?

Dear Reader: You're referring to valsartan, an oral medication that belongs to a class of drugs known as angiotensin receptor blockers, often referred to simply as ARBs. The drug, which works by blocking a certain chemical that causes blood vessels to constrict, is prescribed for individuals with high blood pressure. It is also used to treat congestive heart failure and may be prescribed following a heart attack. Last summer, the U.S. Food and Drug Administration announced a voluntary recall of several blood pressure medications that contain valsartan, due to the presence of a particular chemical which has been identified as a probable human carcinogen. After trace amounts of another type of potential carcinogen were detected, the FDA not only widened the recall to include more blood pressure medications, but it also issued a warning to the manufacturer, Zhejiang Huahai Pharmaceuticals in China.

Since the start of the initial recall in July 2018, investigators uncovered additional concerns, which have resulted in an ever-widening FDA recall. At this time, the agency has increased the recall list to include dozens of drugs used to treat hypertension, all due to the presence of trace impurities that are associated with cancer risk. In addition to many types of valsartan, the recall now includes losartan potassium tablets USP, as well as irbesartan tablets, which are also used to treat hypertension.

The FDA has set up several web pages to help consumers identify whether or not their particular medications are affected.

-- The recalled valsartan drugs are numerous. The list is 11 pages long and the print is pretty small, so get ready to use the zoom function on your device. You can find this list at fda.gov/downloads/Drugs/DrugSafety/UCM615703.pdf.

-- The FDA has also created a website that lists valsartan drugs that are OK and have not been recalled. You can find that one at fda.gov/downloads/Drugs/DrugSafety/UCM615704.pdf.

-- To check whether your type of potassium tablets is on the recall list, visit fda.gov/Safety/Recalls/ucm629261.htm.

-- Information about the recall of irbesartan tablets is available at fda.gov/Safety/Recalls/ucm624593.htm.

The affected drugs are being recalled due to the presence of trace amounts of either N-nitrosodimethylamine (NDMA) or N-nitrosodiethylamine (NDEA), chemical compounds that have been identified as probable carcinogens. The latter chemical has been the subject of research that also associates it with liver and blood cell damage. According to the FDA, the chance of developing cancer as a result of taking these drugs is very small.

If your particular medication is on the recall list, do not stop taking it. The medical risk of suddenly going unmedicated is far higher than the cancer risk posed by the drug. Instead, contact your physician immediately. Let him or her know your prescription is on the FDA recall list and make arrangements to find an alternative as quickly as possible.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o UCLA Health Sciences Media Relations, 10880 Wilshire Blvd., Suite 1450, Los Angeles, CA, 90024. Owing to the volume of mail, personal replies cannot be provided.)

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