health

Improve Sleep Hygiene Before Considering Taking Medications

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | March 15th, 2017

Dear Doctor: I'm 81 and usually go to bed by 10:30 p.m. Although I would like to sleep until 7 or 7:30 a.m., I wake up after 5 or 5 1/2 hours. I've tried 3 milligrams of melatonin, then 5 milligrams. What else can I do?

Dear Reader: Generally, sleep problems get worse as we get older, meaning we have more difficulty falling asleep or staying asleep and our total sleep time is lessened. The elderly in particular have a greatly reduced percentage of deep, or restorative, sleep -- that is, stages 3 and 4. This lack of high-quality sleep causes older people to feel more tired during the day and feel an increased need to take naps. Those naps can significantly affect the sleep-wake cycle at night.

If you're already forgoing daytime sleeping, you'll need to focus on other ways to improve your ability to fall asleep and stay asleep. Start by increasing your amount of exercise and by spending more time outside. Also, assess how much time you spend in the bed not sleeping. If you use the bed as an entertainment platform for watching television or some other form of media, removing the television from the bedroom would be helpful.

Pain and problems with urination or your bowels can also affect sleep, as can caffeine and alcohol. If you have the former, talk to a doctor. If you indulge in the latter, limit their intake.

In a 1999 study published in JAMA, researchers divided 78 people with insomnia into two groups. One group had eight weeks of behavioral therapy that included learning to stop daytime napping, getting rid of media prior to sleep and meditation techniques for relaxation. They compared this group with people who used drug therapy alone for eight weeks. The authors found that those who did the behavioral changes were able to fall asleep more quickly than those who used drug therapy, 55 percent compared to 46.5 percent. Moreover, the behavioral changes had sustained benefit even 12 and 24 months after the therapy, while medication had no sustained benefits.

The medication used in that study was temazepam (Restoril), but many other medications are also available to help people sleep. The problem is that many have side effects, especially for those over the age of 65. The most common side effects are seen with sedative hypnotics such as temazepam, zolpidem (Ambien) and eszopiclone (Lunesta), but also with benzodiazepines such as Xanax, Ativan, Valium and Klonopin. I would caution you not to start these medications.

As for melatonin, it appears to be safe, but doesn't seem to be working that well for you. Medications that work differently than the ones above might provide more relief with fewer side effects. One drug specifically for sleep is Ramelteon, and it binds to the melatonin receptors in the body. Another is the antidepressant Trazodone, which works by increasing levels of serotonin and can cause drowsiness.

But start by improving your sleep hygiene. Don't take naps during the day; decrease your intake of alcohol and caffeine; use the bed only for sleeping; get outside regularly; and exercise. If these methods don't work, a cognitive behavioral therapist who focuses on sleep might be able to help.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Glycemic Index Is Useful for Monitoring Blood Sugar

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | March 14th, 2017

Dear Doctor: I've been reading that choosing foods that are low on the glycemic index is better for your health. What is the glycemic index and why should I pay attention to it?

Dear Reader: The glycemic index, also referred to as the GI, is a system that rates foods based on how quickly the glucose contained within them is absorbed into the bloodstream. Developed to help people living with diabetes to maintain steady blood glucose levels, the GI has become a useful tool for anyone who wants to avoid blood sugar spikes.

The food we eat is broken up into three main categories -- protein, fat and carbohydrates. Of the three, carbohydrates are our main source of energy. The body turns carbohydrates into glucose, a type of sugar, which powers bodily functions. It gives you energy for both mental (your brain is a heavy user of glucose) and physical activity.

However, not all carbohydrates behave the same way after they are ingested. Some, like sweets, baked goods and some fruits and cereals, will cause a sharp rise in blood glucose levels. More complex carbohydrates, like beans or legumes and most vegetables, are digested and absorbed slowly due to their fiber content. When you eat foods that are low on the glycemic index, it leads to a gradual and controlled rise in blood sugar. Foods high on the glycemic index cause blood sugar levels to rise and fall quickly.

The GI is based on a scale of 0 to 100, with pure glucose assigned a value of 100. The more rapidly that foods release their load of glucose into the bloodstream, the higher they rank on the scale. Candy and processed cereals have high glycemic index values. The lowest values are assigned to foods in which glucose is digested and absorbed slowly. For example, cauliflower, spinach, green beans and mushrooms all have a GI of 0.

Why does this all matter?

Chronically high blood sugar levels have been tied to a wide range of health problems, including the risk of developing diabetes, heart disease, nerve damage, cataracts and kidney disease. By learning the GI values of the foods that you eat, you can take control of your diet. You can add foods low on the GI scale that will steady your blood sugar, and eliminate -- or at least limit -- the foods that make your blood sugar jump.

It's important to note that a balanced and healthful diet will be made up of foods from all parts of the GI spectrum. There are several nutritious foods with a high GI value, such as sweet potatoes, which have a GI of 70. Meanwhile, foods with little nutritional value, such as milk chocolate, will rank lower on the GI scale, at about 40.

Foods high in carbohydrates are essential to a healthy diet, but quality matters. Stick with fresh vegetables, fresh fruit, whole grains, legumes and beans. Steer clear of processed foods, which are usually high in refined carbohydrates like white sugar or white flour. And before you make a radical change to the way you eat, be sure to check with your physician.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Niacin Has Proven Effective in Lowering Cholesterol

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | March 13th, 2017

Dear Doctor: I've been taking niacin for years to lower my cholesterol. Do you think it really helps?

Dear Reader: First, let's look at niacin and its role in the body. Niacin is a B vitamin needed to create compounds crucial to cellular function. A shortage of niacin, or vitamin B3, can lead to diarrhea, nausea, vomiting, rash and, when severe, neurologic conditions that manifest as confusion and dementia. Fortunately, because of our varied and plentiful diet, not to mention food supplementation, niacin deficiency is rare in this country.

Some research does support niacin's ability to improve cholesterol levels. In 1955, in one of the earliest studies of niacin, researchers found that doses of 1,000 to 3,000 milligrams significantly lowered total cholesterol levels in men. Niacin has also been found to lower levels of LDL, the so-called "bad" cholesterol, while raising levels of HDL, the so-called "good" cholesterol.

Niacin has an impact in other ways as well. A 2007 study of 30 patients who took 1,000 milligrams daily showed a reduction in the thickness of their carotid arteries' interior lining and lower levels of CRP (C-reactive protein, a marker of inflammation) when compared to a placebo. Further, a 2009 study of a niacin-plus-statin regimen showed that it led to a reduction in a marker for atherosclerosis in the heart.

Such research suggests that niacin could decrease the risk of heart attacks and strokes. The science, however, is less than conclusive.

A 1986 study followed 1,189 men who had a history of heart attack and compared those who took niacin at 3,000 milligrams per day to those who got a placebo. After five years, the niacin group reported fewer heart attacks, but no difference in the death rate. After 15 years, however, the niacin group reported an 11 percent decrease in mortality rates, mostly from a decrease in heart disease.

Studies of niacin in addition to a statin have not shown benefit against either death rates or heart attacks. A 2011 study in the New England Journal of Medicine assessed the impact of 1,500 milligrams of niacin in addition to the drug simvastatin in those with cardiovascular disease. After three years, the authors found no impact on mortality. A 2014 study in the New England Journal of Medicine echoed these findings, with no benefit after 3.9 years of statin-plus-niacin treatment.

It may be that niacin, when taken with a statin, provides no additional bang for the buck. The significant decrease in heart attacks and strokes seen with statin therapy may overwhelm any potential benefit of niacin. Further, as the 1986 study showed, the benefit of niacin may take up to 15 years to show benefit; the trials of statin-plus-niacin were only for three to four years.

Overall, niacin does seem to have beneficial effects on cholesterol and on reducing atherosclerosis, or hardening of the arteries. However, it's not as powerful as a statin in decreasing rates of heart attacks, and the benefit might not become evident for years.

If you cannot tolerate a statin, niacin may be a good option. But discuss it with your doctor.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

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