health

Nonallergic Rhinitis Often Linked to Hyper-Responsive Nerves

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | March 30th, 2018

Dear Doctor: I have been plagued with clear nasal drip for a couple of years. The constant dripping is most prevalent when I eat, lift something heavy or even just get up from a chair. I have tried various antihistamines and nasal sprays. What else is there?

Dear Reader: First, let's look at the root of your problem: rhinitis, the inflammation of the mucous membranes within the nose. This common condition, which can cause nasal congestion, runny nose and post-nasal drip (the symptom you describe), affects 10 to 40 percent of the population in industrialized countries.

People may think that allergies are the cause of their symptoms, but chronic nonallergic rhinitis is the cause a third of the time. Notably, although people with allergic rhinitis often have a history of congestion before the age of 20, 70 percent of those with nonallergic rhinitis have no nasal symptoms until after age 20.

Many doctors, including myself, previously referred to the condition as autonomic rhinitis because of its connection to the autonomic nerves that go to the nose. These nerves can become hyper-responsive, leading to nasal congestion and runny nose upon exposure to environmental stimuli, such as changes in temperature, especially cold temperatures. Autonomic nerves can also cause nasal symptoms when a person eats spicy foods, consumes hot foods or drinks, exercises, lifts heavy objects or simply changes position.

But the autonomic nerves may not be the only factor at play. An inflammatory response can also occur with nonallergic rhinitis, caused by white blood cells that become active in response to chemical irritants like cigarette smoke, perfume, cologne, scented products and pollution. This inflammatory response can compound the autonomic response; it could also potentially be the root cause of your post-nasal drip.

The first aspect of treating nonallergic rhinitis is to rule out an allergy or specific environmental stimulus. The second step is to assess the use of nasal decongestants, such as Afrin or Sudafed. Chronic use of these medications by tablet or spray can cause a rebound of congestion when the medication is stopped. Heartburn, or acid reflux, also should be addressed because it can lead to rhinitis as well.

As for treatment, the oral antihistamines often used to treat allergies may not be helpful against nonallergic rhinitis, because allergies aren't the cause. Nasal antihistamines have shown benefit in treating nonallergic rhinitis, however. So too have nasal steroids, which decrease the inflammation in the nose. The latter drugs need to be used for more than a week to show an effect, however, and some doctors are concerned about longer-term use.

It seems likely you have an autonomic component to your symptoms. If so, talk to your doctor about ipratropium nasal spray (Atrovent). It blocks nerve receptors in the nose that are part of the autonomic nervous system. Your doctor may recommend its use before eating, before heavy exercise and, if necessary, before exposure to cold and dry conditions. If that doesn't work, a nasal steroid and possibly a nasal histamine are other options.

Some patients with nonallergic rhinitis may eventually develop allergies and even asthma, so please follow up with your doctor if your symptoms worsen.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Possibility of Cattle Eye Worm Infestation Exceedingly Rare

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | March 29th, 2018

Dear Doctor: Please tell me more about the recent story in the news about the young woman who spent time on a ranch and then found worms living inside her eyes. We are cattle ranchers, and now I'm worried about my husband and kids.

Dear Reader: You're correct -- a 26-year-old woman from Oregon discovered that she was infected with Thelazia gulosa, a parasite commonly known as the cattle eye worm. Dogs and other canids, cattle and horses are the most common hosts. We hope that you'll be reassured to learn that this is the first reported case of infestation of the cattle eye worm in a human host.

For those of you who missed the (fairly robust) media coverage of the story, here's the gist. In 2016, a young woman who was working on a commercial fishing boat in Alaska thought she felt an eyelash in her eye. Although she rubbed her eye and flushed it with water, the scratchy, itchy sensation persisted. After a moment of looking in a mirror, she finally saw something above the lower lid of her left eye and lifted it out. Instead of one of her own brown lashes, she was looking at a slender white thread about a half-inch long -- a living worm.

She went to an urgent care clinic and an ophthalmologist before seeing an infectious disease specialist. A team of parasitologists at the Centers for Disease Control and Prevention eventually nailed the diagnosis. In all, a total of 14 worms were removed from the young woman's eye. It was by reading a research paper written in Germany in 1928 that a scientist from the CDC's Parasitology Reference Diagnostic Laboratory finally identified the cattle eye worm.

So how did this happen?

Infestations of Thelazia, a genus of nematode worms that live as parasites in the eye and its surrounding tissue, are most commonly seen in animals and birds. Their spread to humans is extremely rare. In fact, just 10 other cases of eye worm infestation have ever been reported in North America. The most recent case in the United States was reported more than two decades ago. None of those 10 cases involved the cattle eye worm.

Although it's impossible to know for sure, the thinking is that the young woman may have picked up the parasite while spending time at an inactive cattle ranch. The worms are carried by the flies that you see buzzing around the faces of cattle and horses. The worm larvae, which reach maturity inside the digestive tracts of the flies, move to their next host when the fly lands on the cow's eyeball to drink. There, the eye worm grows to adulthood and produces more larvae, which are then picked up by new flies.

The good news is that because eye worms need the flies to reach maturity, their life cycle ends in a human host. With those 14 worms removed from her eyes, the young woman's infestation was over. No permanent damage was done.

As for the rest of us, even if we spend time near cattle or horses, the chances of picking up the parasite are extremely small. Be sure to keep flies away from your face and eyes, and if one lands, remove it promptly.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Origins of Annoying Seborrheic Keratoses Are a Mystery

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | March 28th, 2018

Dear Doctor: I'm 88 and have small, brown, rough -- and very itchy -- spots that develop on my back and other areas. If I can scratch them off, the itching goes away. One spot that I didn't scratch off is now embedded and I can't get it off. Two dermatologists have basically said, "It's your age. Live with it." Isn't there another answer?

Dear Reader: You seem to be describing seborrheic keratoses (the singular is keratosis). These scaly, thickened growths appear to be "stuck" on the skin, sort of like wall putty. Like wall putty, these lesions can often be scraped off; unlike putty, however, they can come back on their own. Although most lesions are brown, they can also be white, black, yellow or grayish. They normally appear after the age of 50 (so, yes, they are common at your age), but can begin in one's 30s.

Seborrheic keratoses can occur anywhere upon the body except the palms and soles, and the lesions are more likely to occur in sun-exposed areas of the body. Some people have a few lesions; others may have hundreds. Such keratoses can be irritated by clothing -- especially bras -- leading to itching, pain and bleeding.

Although the sun may be a factor in the development of such lesions, their origin largely remains a mystery. We do know that when normal cell death is disrupted, skin cells accumulate, bunching up on top of each other. It's possible this disruption is caused by a genetic mutation in the skin cells; in fact, the likelihood of such lesions does seem to be influenced by genetics.

Because the lesions resemble warts, many medical experts have postulated that the human papilloma virus (HPV), which creates warts, is the cause. A 2004 study took biopsies of seborrheic keratoses from 55 people and compared them with 48 biopsies of normal skin in other individuals. Although the researchers found HPV in 76 percent of the keratoses, they couldn't conclude that HPV was the cause.

Doctors are usually not worried about seborrheic keratoses (as your experience attests), because the likelihood of them becoming cancerous is extremely small. But although the lesions are not harmful, they're not pretty either, which is the primary complaint against them. The basic treatment is to try to destroy them, especially if they're causing irritation. Biopsies are rarely necessary unless something about the lesion looks cancerous.

Liquid nitrogen is often the first choice of doctors trying to destroy seborrheic keratoses. It makes the lesions blister and then fall off -- which may be a good option if it is overly itchy or painful -- but the lesions can return. Doctors can also shave off the lesions, but this can lead to bleeding and scarring. Laser therapy can remove the lesions as well, but is rarely used.

As for topical treatments, the retinoid cream tazarotene can diminish seborrheic keratoses, as can a topical medication used for warts, imiquimod.

In the future, when science has figured out the cause for seborrheic keratoses, doctors will be more apt to prevent these lesions from occurring, perhaps through a vaccine. In the meantime, if these lesions are not physically irritating, there is no pressing need for treatment. So, you may just have to live with it.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

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