health

Dementia Can Be Diagnosed With a Battery of Tests

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | February 12th, 2018

Dear Doctor: How is one screened for/diagnosed with Alzheimer's or other forms of dementia? What type of doctors does one see? What sorts of tests do they run? It runs in my family, and lately I've been forgetting conversations soon after they happen. But I don't know where to look for answers.

Dear Reader: Your concern is understandable. The degeneration of the brain's ability to incorporate new information -- and the loss of the hardwiring that controls our everyday tasks -- affect not only an individual but everyone who cares for that person as well. Further, the genetic linkage is greatest for people with a parent or sibling who developed dementia prior to the age of 65. (The linkage grows progressively weaker with the family member's age of diagnosis, so much so that if the person was diagnosed after 85, one's own risk is no different than if there were no family history.)

Further, the rates of dementia are increasing in this country, with Alzheimer's dementia affecting 5.4 million people in the United States in 2016. Some of this may be due to our ability to diagnose the disease, but our increasing rates of risk factors -- diabetes, obesity and lack of physical activity -- play a role as well. The majority of people are diagnosed after the age of 65, with the overall incidence of dementia doubling every 10 years after the age of 60.

Diagnosis typically starts with your primary care doctor. While blood tests can pick up some non-Alzheimer's causes for memory loss, such as B12 deficiency, the standard screening exam is the Mini-Mental Status Examination (MMSE), a memory and writing test. That said, another test, the Montreal Cognitive Assessment (MoCA), has greater sensitivity in identifying losses in the abilities to use language and perform tasks -- both common markers for encroaching dementia -- so your doctor may use this as well.

These tests can effectively identify people who already have dementia, but they are less effective at identifying people in the early stages of memory loss or those who have memory loss but also have a higher level of brain function. In these cases, much longer and more formal neuropsychological tests may be necessary. This testing is often done by a psychologist associated with a neurologist.

A neurologist may also order imaging tests of the brain. These tests can include an MRI, positron emission tomography (a PET scan) and possibly functional brain imaging that assesses areas of the brain with low activity. Although some findings might suggest Alzheimer's, these tests are used primarily to rule out other causes; they can't yield a definitive Alzheimer's diagnosis.

The potential to use cerebrospinal fluid biomarkers to help diagnose Alzheimer's disease is still in the investigational phase and unlikely to be used by a neurologist currently.

So start by talking to your primary care doctor about the change in your memory, how long it's been happening and whether it's rapidly getting worse. Your doctor will likely conduct a standardized test for memory, along with blood work to rule out other causes of memory loss. If that suggests a problem, but no other physical cause, you should see a neurologist for more formal testing.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Study Looked at Grandparents' Influence on Grandkids' Health

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | February 10th, 2018

Dear Doctor: I read that grandparents can increase a child's cancer risk by encouraging bad behaviors. Quite frankly, I'm offended by this. Couldn't they also improve a child's health? When our grandkids are visiting, we get them to eat much healthier food than they typically get at home.

Dear Reader: We confess that we cringed a bit as we read some of the headlines that the study you are referencing has generated. A very important message -- the rules of health and nutrition hold true no matter who is breaking them -- is getting buried beneath needless snark.

To answer your question: Yes, by offering the right nutritional guidance and making wise food choices, grandparents can absolutely have a positive effect on a child's health. We're happy to hear that you focus on a healthful diet when your grandkids are around, but suspect you are far from alone in this endeavor.

So how did this "grandparents may be bad for kids' health" conversation get started?

Researchers from the University of Glasgow in Scotland were interested in learning what role, if any, additional caregivers may have on the risk factors for non-communicable diseases in children. In the majority of cases, these secondary caregivers were grandparents.

The researchers noted that the positive habits and behaviors that can help avert up to 40 percent of the cancers that develop in adulthood are actually acquired in early childhood. These include sticking to a healthful diet, getting regular exercise, not using tobacco products, not abusing alcohol, limiting or mitigating sun exposure, and avoiding excess weight gain.

The question then became what sort of effect the grandparents' approach to those positive behaviors had on the children's cancer risk. To that end, researchers analyzed data collected in 56 studies that had been conducted in 18 different countries.

This new study, which was published last November in the journal PLOS One, found that the primary risky behavior that grandparents took part in was overfeeding their grandchildren. That is, the grandparents took a more indulgent approach to their grandchildren's diets. They offered them more treats than their parents did and provided larger portions during meals. This meant the kids were eating too many calories, many of them coming from sugar, fat and processed foods. This resulted in the grandchildren gaining weight.

Another factor was activity levels, which were lower among children when being cared for by grandparents than when they were with their parents. In some cases, the children were exposed to tobacco products and secondhand smoke in their grandparents' homes. The upshot of all these behaviors was a measurable increase in the risk factors that can lead to heart disease, diabetes and even cancer later in life.

One thing the researchers were careful to address, and which didn't appear in the stories we read, was why this was happening. In some countries, excess weight was a cultural sign of health and prosperity. For some grandparents who had been raised in wartime or in poverty, abundant food was a symbol of safety and stability.

Rather than being uncaring or careless, many of the grandparents in the study believed they were helping the children.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Erosive Osteoarthritis Typically Affects the Joints of the Hands

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | February 9th, 2018

Dear Doctor: I was just diagnosed with erosive osteoarthritis. What can you tell me about it? I have it mainly in my hands and feet.

Dear Doctor: First, let's explain the most common form of arthritis, known simply as osteoarthritis, which develops slowly over time due to complex changes in cartilage, bone and joint linings. Formerly known as "wear and tear" arthritis, osteoarthritis has no inflammatory component and typically occurs in multiple joints throughout the body. Erosive osteoarthritis, on the other hand, is an inflammatory form of the disease that occurs primarily in the hands and, sometimes, in the feet.

In the hands, erosive osteoarthritis develops earlier in life than does typical osteoarthritis, usually between the ages of 40 and 50. It's most commonly diagnosed in women (rarely men) at the time of menopause, suggesting that loss of estrogen is a factor.

Unlike typical osteoarthritis, erosive osteoarthritis has a sudden and aggressive onset. The hand joints become warm, red, swollen and tender, making it difficult to move the fingers. With this degree of inflammation, the disease can look much like rheumatoid arthritis, but unlike rheumatoid arthritis, erosive osteoarthritis involves the joints at the end of the fingers. Bony swellings develop upon these joints, creating what appears to be nodules. The joints lose their structure so much that the finger bones move laterally in opposite directions, making the fingers look wavy instead of straight.

The inflammation can cause cartilage and bone in the joint to erode, giving the disease its name. In severe cases, the joints fuse, making movement almost impossible. The inflammatory course of the disease can last for months or come and go for up to five years. However, even when the inflammation subsides, the damage leads to long-term deformities and loss of function of the involved joints.

There are no specific lab tests to diagnose erosive osteoarthritis. Your doctor may have done blood tests to rule out diseases such as rheumatoid arthritis, but the symptoms in your hands and feet were his or her greatest clue. Patients may have some elevated inflammatory markers, but the disease is primarily diagnosed by a person's symptoms. X-rays of the hands can show specific erosions in the bones that are unique to the disease.

Decreasing inflammation is the first place to start. This can be done with topical anti-inflammatories such as diclofenac or oral anti-inflammatories such as ibuprofen, naproxen, meloxicam or celecoxib. Drugs used for rheumatoid arthritis can also ease the inflammation and erosion of erosive osteoarthritis. These include hydroxychloroquine, methotrexate and the injectable drug Humira. For severe cases, injecting steroids directly into the finger joints can decrease deformities. Also, though the data are limited, one study showed a decrease in erosions and improvement of symptoms among people taking 800 milligrams of the supplement chondroitin in addition to Naprosyn (naproxen).

Physical therapy can also improve finger mobility and reduce the likelihood that the fingers will become excessively crooked.

My advice is to treat the disease early. Although the inflammatory portion of erosive osteoarthritis is relatively short, controlling the inflammation with medication and getting hand therapy will reduce the likelihood of the deformities that can happen with the disease.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

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