health

Recent Bacterial Outbreak Linked to Pet Store Puppies

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | January 25th, 2018

Dear Doctor: We just got a new puppy, but I'm almost afraid to let my child play with it. I read a news story that said puppies have been linked to some sort of bacterial infection. What should I do?

Dear Reader: The news you're referring to is the outbreak of campylobacteriosis, an infectious disease linked to puppies purchased from Petland, a national chain of pet stores. Campylobacter bacteria is one of the most common sources of diarrheal illness in the United States. Although campylobacteriosis is most often associated with raw or undercooked meats, the bacterium can be present in the feces of dogs and cats as well.

What made this particular outbreak problematic was that the bacteria involved proved to be resistant to the first-line antibiotics that are most commonly recommended. This type of resistance is associated with an increased risk of hospitalization, the development of a bloodstream infection, or in extreme cases, treatment failure in patients.

The outbreak, which began in September 2017, eventually spread to 17 states. As of mid-December, laboratory tests confirmed illness in 97 people linked to this outbreak. And as of this writing, about 25 percent of them were hospitalized. No deaths had been reported.

If your puppy came from a Petland store (there are about 80 nationwide), you should contact the company. As requested by the Centers for Disease Control and Prevention, which tracks these types of outbreaks, Petland will help you to determine whether your puppy is likely to have been infected.

The truth is that virtually every living creature, humans included, is a carrier of something that can be transmitted to the people (and animals) around them. While there is growing evidence that repeated contact with pets and farm animals can help to build up the immune system, it's important to be aware that potentially dangerous organisms can be transmitted as well.

Psittacosis, a respiratory infection caused by a bacterium, is sometimes seen among owners of pet birds, like parrots and cockatiels, and in poultry, like turkeys or ducks. The Toxoplasma parasite, sometimes found in cat feces, has an estimated 30 million carriers in the U.S. alone. (Most have no symptoms thanks to the immune system.) Roundworm, a parasite that at some point infects most dogs, particularly puppies, can also be transmitted to humans.

The point here isn't to alarm but rather to encourage good pet hygiene. With just a few easy steps, you can keep your family safe and go on to enjoy the multitude of benefits afforded by having a dog in your life.

-- Be meticulous about keeping your yard cleared of dog feces, picking it up as soon as possible.

-- Avoid physical contact with feces and urine by wearing gloves or using a sturdy pooper scooper while cleaning up.

-- When discarding feces into the trash, put it into an impermeable bag and tie it off.

-- Wash your hands when you're finished with scooping duties and after extended physical contact with your pet.

Finally, for your puppy's safety as well as your own, take him for regular veterinary visits, have his stool checked as needed, and make sure he's up to date on vaccinations.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Aplastic Anemia Can't Simply Be Cured With Iron Supplements

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | January 24th, 2018

Dear Doctor: I have aplastic anemia. It is hard to explain this to people. Most of them hear the anemia part and get stuck there. I hear often: "Just take some iron" or, "My aunt had that and was cured with B12 shots." How do I quickly explain it better?

Dear Reader: How frustrating this must be for you. To put it simply for people, you could say that aplastic anemia is a bone marrow disease that leads to bone marrow failure. If they stare at you glassy-eyed, you might want to leave it at that, but if they're truly interested, you can try a longer explanation.

Start by saying that aplastic anemia is a rare disorder, diagnosed in one in every 500,000 people per year. The incidence is two to three times higher in Asia. Then you can explain that the function of the bone marrow is to produce red blood cells, white blood cells and clotting cells called platelets. The bone marrow contains specific cells, called hematopoietic stem cells, that are necessary to produce all of these. With aplastic anemia, these stem cells are damaged, so all of the cell lines are diminished.

Most cases of aplastic anemia are due to an attack by the body's immune system on the bone marrow, which destroys the hematopoietic stem cells. The cause of this attack is unknown, but a virus, chemical, drug or mutation may be the instigator, altering the immunity so that the white blood cells see the stem cells as foreign and thus attack them.

As the name implies, the disease causes anemia, which is a lowering of the red blood cell count. This can lead to significant fatigue and stress on the heart, which has to pump this deficient blood to the rest of the body. In addition, depletion of the white blood cells leads to an increased risk of pneumonia, urinary tract infections and severe bloodstream infections. When the white blood cell counts are chronically low, patients face a risk of invasive fungal infections, which can lead to death. Further, the lowering of the platelet counts increases the risk of bleeding due to the blood's decreased clotting ability. Ultimately, mutations in the bone marrow can lead to leukemia.

Aplastic anemia treatment depends upon the severity of the disease, the patient's age and whether the patient has other illnesses. You might want to explain that, because of the disease's potential complications, treatment is much more aggressive than taking iron or B12 supplements.

In fact, the treatment with the greatest chance of success is the transplantation of hematopoietic stem cells from a donor -- a difficult treatment with severe side effects. And although transplantation can lead to prolonged survival, it also often fails. This approach, which requires a compatible donor, is recommended for healthier patients and those younger than 50. Another method of treatment is the suppression of the immune system's attack on the cells in the bone marrow. This requires a combination of medications, which can also have significant side effects.

Maybe this explanation will help people understand the severity of aplastic anemia and to be more understanding of what you are going through. If not, at least be assured that some people do understand your battle -- and wish you strength and recovery.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Cochlear Implants Can Be Adjusted to User's Hearing Needs

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | January 23rd, 2018

Dear Doctor: I'm contemplating a cochlear implant for my right ear. How do they work, and what is the success rate of such procedures?

Dear Reader: Unlike a hearing aid, which is a mechanical apparatus that amplifies sound, a cochlear implant is a medical device that delivers electrical stimuli directly to the auditory nerve. Hearing aids can be helpful in cases of mild to moderate hearing loss. But for individuals whose hearing loss is severe or profound, a cochlear implant can help.

That said, it's important to understand that a cochlear implant can't offer the same hearing experience as the human ear. And to understand why, we first need to talk a bit about how the ear works. (Are any of our regular readers surprised?)

When we hear a sound, it's because a complex series of functions have taken place. It begins as vibrations traveling through the outer, middle and inner ear. On each phase of that journey, a series of remarkable structures transform those vibrations until they reach the brain and are interpreted as the countless sounds -- and noises -- of the world around us.

Let's say it's raining. The vibrations from droplets striking various surfaces are "collected" by the funnel of the outer ear and an inner auditory canal. At the end of this canal sits the eardrum, which connects to a trio of tiny bones. These pick up and amplify the vibrations, and transmit them to the snail-shaped cochlea in the inner ear. Within the cochlea, a fluid begins to ripple. When tiny hair-shaped sensory cells touch a membrane, chemicals that create an electrical signal are released. This signal travels along the auditory nerve to the brain, which presents us with the sound of rainfall.

With a cochlear implant, which is made up of two parts, vibrations bypass the hair cells of the inner ear. Instead, the speech processor, worn behind the ear like a hearing aid, sends the information directly to a receiver-stimulator, a small device that is surgically placed beneath the skin. Electrodes from the receiver connect via the cochlea to the auditory nerve. When the processor picks up sound, the receiver turns it into electrical impulses and sends them to the brain. But because the hair cells within the cochlea, which give us the countless nuances of sound, are not involved, the hearing experience is not the same.

How well someone does with a cochlear implant depends in part on what degree of hearing they began with. Learning to interpret the impulses sent by the implant takes practice and can be challenging. Like hearing aids, there are several varieties of implants, and all can be adjusted to best fit the user's needs.

Risks include nerve injury, infection, meningitis, numbness around the ear, vertigo, tinnitus and the risks associated with anesthesia during the initial operation. Some implants fail and must be removed. For people with implants, scans like an MRI may not be possible.

Today, well over 60,000 adults in the United States use implants. If you do move forward, we suggest getting in touch with an organization that offers assistance to people who are deaf and hard of hearing. Also, going to a support group for cochlear-implanted patients can be a good way to get firsthand feedback.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

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