health

Comparing Surgical Procedures to Clear Carotid Artery Plaque

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | May 10th, 2017

Dear Doctor: My cardiovascular surgeon tells me medicine has mostly abandoned shunt and stent placements as a solution to carotid artery plaques. Instead, doctors are returning to the older "Roto-Rooter" procedure because patient outcomes have proven less problematic. What's your take on this?

Dear Reader: Let's start with an anatomy lesson. The common carotid arteries are major suppliers of blood to the brain. You have two of them, and you can feel their pulse at the side of your neck, lateral to your Adam's apple (thyroid cartilage). They split in the neck to become the external and internal carotid arteries, which supply blood to the majority of the brain.

Turbulent blood flow at the location of these splits contributes to the formation of plaque within the internal carotid arteries, as do other factors like high blood pressure, diabetes and smoking. This plaque can rupture and cause closure of the artery; or a portion of the plaque can break off and lodge in a smaller artery. In either circumstance, a stroke occurs -- leading to a significant loss of neurologic function. Thus, if the internal carotid artery is significantly closed with plaque, it is necessary to clear the plaque.

What you describe as a Roto-Rooter procedure is called a carotid endarterectomy. A surgeon performs an endarterectomy via an incision in the neck. Taking care to maintain blood flow to that side of the brain, he or she clamps the internal carotid artery, makes an incision in the artery and locates the plaque. The surgeon then frees the plaque from the lining of the artery and removes it before closing the blood vessel and placing a patch on the artery to prevent complications.

Obviously, the procedure is not without its risks. The death rate from endarterectomy varies between 0.5 and 3 percent. Also, the rate of having a stroke during the procedure ranges between 0.25 and 3 percent and depends on how severe the plaque is and the skill and experience of the surgeon.

Carotid artery stenting is a different type of procedure in which the surgeon places a catheter into a major artery (usually the femoral artery in the groin), then moves it via wire up to the internal carotid artery. The surgeon then dilates the artery (if necessary) and lodges the stent into its lining.

On the surface, stenting may sound less dangerous, but studies have not found this to be the case. A 2012 analysis of 16 studies found that, in the 30 days after the procedure, stenting had a higher rate of combined death and stroke (8.2 percent) compared to endarterectomy (5 percent). A separate study also linked stenting to more minor strokes.

But note that the difference in death and major stroke was not seen among patients less than 70 years of age. And other studies have shown that, over timeframes of 4.2 and 10 years, the rates of major strokes and death show less of a benefit with the carotid endarterectomy versus stenting.

Still, as of now, research suggests that the carotid endarterectomy is clearly the better procedure, especially if you're over the age of 70.

But note that each patient is different. In difficult surgical situations, stenting remains a good alternative, and with newer carotid stenting techniques currently in development, the choices for individuals will continue to evolve.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Inflammation Is Part of Body's Healing Process

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | May 9th, 2017

Dear Doctor: It seems as though we're hearing more and more about inflammation and how it causes disease. What is inflammation and how does it work? And is it really possible that what you eat makes a difference?

Dear Reader: You've asked some pretty big questions, so we're going to answer them in two parts. In this column, we'll explore inflammation itself. We'll address whether what you eat can have an effect on inflammation (spoiler alert -- yes) in our next column.

First of all, you're correct that there's been an increase in awareness about the concept of inflammation in the last few years. At its most basic, it's the body's localized response to injury or infection. When you catch a cold, scrape your knee or get a sunburn, inflammation is the cause of the swelling, heat, pain and redness that follow. And while it sounds simple, the pathways and mechanisms of inflammation, as well as the many ways it can act upon the body, are really quite complex.

The human body is perpetually on guard for anything that may harm it. This includes physical injury to skin, bone, organs or tissues, or potentially dangerous invaders such as bacteria, viruses, pathogens or other harmful stimuli. When damage is detected, the body's immune system rallies. Many different types of immune cells "wake up" and begin to release a variety of substances, each of which causes a rapid series of protective responses. This is part of a process known as acute inflammation.

Blood vessels expand so they can quickly send additional blood to the injured area. They will also temporarily become more permeable, so as to flood the site of damage with specialized chemicals produced by white bloods cells, which are our first line of defense against infection. These responses are what cause the injured area to turn red, feel hot and become swollen.

Some of the substances released in the immune response will also cause surrounding nerves to send pain signals to the brain. That causes your attention to be drawn to the site of the injury, which you will then shelter from further damage. For example, when you sprain your ankle, the pain and swelling automatically lead you to favor the injured side.

Without the inflammation response, our wounds and injuries would not heal. However, things can go awry. Sometimes the immune system will issue an inflammation response against otherwise innocuous substances, like pollen, certain foods or pet dander. The result is allergies, which can range from annoying to life-threatening.

Even more challenging is chronic inflammation, an immune response that lasts for months or even years. It happens when the body targets its own cells and tissues, which can result in disease. For example, rheumatoid arthritis is caused when joints throughout the body are permanently inflamed. Psoriasis is a chronic skin disease caused by inflammation. Inflammation of the bowel can cause conditions like Crohn's disease, celiac disease and ulcerative colitis. And inflammation plays a role in cardiovascular disease, heart attack and some cancers.

In our next column, we'll dive into the second half of your question -- can food have an effect on inflammation?

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

health

Meloxicam Can Be Effective When Used on Limited Basis

Ask the Doctors by by Eve Glazier, M.D. and Elizabeth Ko, M.D
by Eve Glazier, M.D. and Elizabeth Ko, M.D
Ask the Doctors | May 8th, 2017

Dear Doctor: I've suffered joint pain for years. Being prescribed 15 milligrams of meloxicam has been wonderful. What are your thoughts on meloxicam use?

Dear Reader: Meloxicam (Mobic) is a non-steroidal anti-inflammatory drug (NSAID) that, like all such drugs, inhibits the formation of the enzyme cyclooxygenase (COX). This inhibition leads to a decrease in the production of molecules that boost inflammation and help the blood clot.

There are two forms of the COX enzyme, aptly named COX-1 and COX-2. COX-1 is involved in protecting the lining of the stomach, promoting the blood's clotting ability and aiding kidney function. COX-2 is involved in the inflammatory response in the body. Many of the side effects seen with older NSAIDs such as ibuprofen, naproxen and diclofenac are related to the inhibition of COX-1. The side effects include gastritis or gastric ulcers, blood thinning and kidney damage. Inhibiting COX-2 leads to a decrease in inflammation and a decrease in pain.

Meloxicam at low doses (7.5 milligrams) inhibits COX-2 and not COX-1. That means it can reduce pain and inflammation without irritation of the stomach lining or an increased risk of stomach ulcers. Research has found that serious upper gastrointestinal events at the 7.5 mg dose occur in fewer than 1 in 3,000 people. But note that follow-up studies didn't last more than 60 days, so it's unclear if these rates would hold up over the long term.

Further, at low doses, meloxicam may not trigger the kidney problems that other NSAIDs cause. The rates of heart attacks appear comparable to those of other NSAIDs, with a slight increase in risk at all doses.

However, when meloxicam dosage is increased to 15 mg, the medication does inhibit COX-1, leading to a significant increase in the rates of serious upper gastrointestinal events.

One study found that, while the number of events was less than with the NSAID naproxen, the number of events at 15 mg was six times higher than the lower dose of meloxicam (1 in 500 people). Another study showed a greater proportion of people taking 22.5 mg of the drug for 12 weeks had a slight decrease in kidney function. This was not seen at the 15 mg dosage.

Lastly, for people on two types of blood pressure drugs -- ACE-inhibitors and angiotensin receptor blockers -- meloxicam (like other NSAIDs) may make those medications less effective.

In summary, meloxicam works well for pain and swelling. The higher doses do decrease pain more than the 7.5 mg dosage, and the medication is comparable to the NSAID diclofenac for both pain relief and decreasing inflammation. I have frequently recommended the medication for joint inflammation, bone bruises and pain from fractures and tendonitis, and it's worked well for the majority of my patients. For older adults, I lean toward the 7.5 mg dose, but I have recommended 15 mg in more severe cases. Some of the latter group have complained of gastrointestinal discomfort, but this stopped when they discontinued the medication. I rarely give this medication for greater than one month, but have had some patients with severe arthritis who have been on this medication for years.

I don't know how frequently you are using meloxicam, but if you're using it on an as-needed basis, it should be safe. If you're using this medication daily, you should consider its potential for side effects.

(Send your questions to askthedoctors@mednet.ucla.edu, or write: Ask the Doctors, c/o Media Relations, UCLA Health, 924 Westwood Blvd., Suite 350, Los Angeles, CA, 90095. Owing to the volume of mail, personal replies cannot be provided.)

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